We solved TrkB,
a previously undruggable target

Over 30 years of scientific work and 34,000+ publications validate the target

Meet the team

Our experienced multidisciplinary international team includes the original inventors and qualified drug developers from the global pharmaceutical industry partnering with leading drug discovery CROs.

  • Jami Mandelin

    Co-founder, CEO
    14y of commercial & R&D experience from Faron Pharmaceuticals, Novartis, Roche

  • Georgios Trichas

    Chief Business Officer
    15y of commercial experience  from Achilles Therapeutics, Wellcome Trust

  • Matti Karvonen

    Chief Medical Officer
    20y of drug development experience from Orion Pharma, Faron Pharmaceuticals, Roche, Biogen

  • Peter Gallagher

    Co-founder, Medicinal Chemistry Lead
    36y of medicinal chemistry experience in CNS drug discovery from Eli Lilly with 20+ patents

  • Giray Enkavi

    Co-founder, Principal Scientist Modeling
    20y of biophysics and biomodelling experience from University of Illinois and University of Helsinki

  • Rafael Moliner 

    Co-founder, Biology Lead
    12y of experience in TrkB biology from University of Helsinki

  • Tim Schulz-Utermoehl

    DMPK Lead 
    23y of neuroscience DMPK experience from MSD, AstraZeneca UK, Shire UK, Sygnature

  • Eero Castrén 

    Co-founder, Board member
    Professor, Research Director, Neuroscience Center, University of Helsinki

    World-leader in BDNF and TrkB biology and antidepressant drug research

    Landmark 2023 Nature Neuroscience paper demonstrated role of TrkB receptor in mediating the positive effects of psychedelics

    241 papers published with more than 28,000 citations

  • Ilpo Vattulainen

    Co-founder, Board member
    Professor in Biological Physics, University of Helsinki

    World-leader in in-silico biomolecular simulations and AI/ML

    Revealed the structure of TrkB embedded in cholesterol enriched membranes dimers with and without different ligands

    300+ papers published with more than 26,000 citations